Ka taea te kite i te formate hei pou tuarā o te ōhanga waro-kore, i hangaia mai i te CO2 mā te whakamahi i ngā tikanga (hiko)matū, ā, i hurihia hei hua tāpiri uara mā te whakamahi i ngā rerenga whākōkī, i ngā moroiti hangarau rānei. Ko tētahi taahiraa nui ki te whakawhānui ake i te whakauru o te formate hangai ko tōna whakaiti i te formaldehyde i roto i te uaua thermodynamics, e puta mai ana i konei hei huringa tae kōwhai. Whiwhinga: Institute of Terrestrial Microbiology Max Planck/Geisel.
Kua waihangahia e ngā kaipūtaiao o te Max Planck Institute tētahi ara pākia hangai e huri ai te hauhā waro ki te formaldehyde mā te āwhina o te waikawa formic, e tuku ana i tētahi huarahi waro-kore ki te whakaputa rauemi whai hua.
Ehara i te mea ko ngā ara anabolic hou mō te whakapūmau i te hauhā waro anake te āwhina ki te whakaiti i ngā taumata o te hauhā waro i te āhuarangi, engari ka taea hoki te whakakapi i te hanga matū tuku iho o ngā rongoā me ngā kai hohe ki ngā tukanga koiora waro-kore. E whakaatu ana ngā rangahau hou i tētahi tukanga e taea ai te whakamahi i te waikawa formic hei huri i te hauhā waro hei rauemi whai hua ki te umanga matū koiora.
I te mea kua piki ake ngā tukunga hau kati kōtuhi, he take nui te pupuri waro, te pupuri rānei i te hauhā waro mai i ngā pūtake tukunga nui. I roto i te taiao, kua roa te mimiti o te hauhā waro, engari kāore tōna kaha i te rawaka hei whakakapi i ngā tukunga a te tangata.
Ko ngā kairangahau i arahina e Tobias Erb o te Institute of Terrestrial Microbiology. Ka whakamahia e Max Planck ngā taputapu taiao hei whakawhanake i ngā tikanga hou mō te whakatika i te hauhā waro. Kua angitu rātou inaianei ki te whakawhanake i tētahi ara pākia horihori e whakaputa ana i te formaldehyde tino tauhohe mai i te waikawa formic, he takawaenga pea i roto i te photosynthesis horihori. Ka taea e te formaldehyde te uru tika ki roto i ētahi ara pākia hei hanga i ētahi atu matū whai hua me te kore he pānga paitini. Pērā i te tukanga taiao, e rua ngā kai matua e hiahiatia ana: te pūngao me te waro. Ko te tuatahi ka taea te whakarato ehara i te mea mā te rā tika anake, engari mā te hiko hoki - hei tauira, ngā kōwae rā.
I roto i te mekameka uara, he rerekē ngā pūtake waro. Ehara i te mea ko te hauhā waro anake te kōwhiringa i konei, engari e kōrero ana mātou mō ngā matū waro takitahi katoa (ngā poraka hanga C1): te hauhā waro, te waikawa formic, te formaldehyde, te methanol me te methane. Heoi, he tino paitini te nuinga o ēnei matū, mō ngā mea ora (te hauhā waro, te formaldehyde, te methanol) me te ao (te methane hei hau kati kōtuhi). I muri i te whakakorenga o te waikawa formic ki tōna hanganga taketake, ka taea e te nuinga o ngā moroiti te manawanui ki ngā kukū tiketike o taua mea.
"He tino whai hua te waikawa formic mō te waro," te whakanui a Maren Nattermann, te kaituhi tuatahi o te rangahau. "Engari he tino nui te kaha e pau ana ki te huri i te formaldehyde i roto i te vitro." Nā te mea kāore e ngāwari te huri i te formate, te tote o te formate, ki te formaldehyde. "He arai matū nui kei waenganui i ēnei ngota e rua, ā, i mua i te taea e tātou te whakahaere i tētahi tauhohenga tūturu, me wikitoria e tātou mā te āwhina o te kaha matū koiora - ATP."
Ko te whāinga a ngā kairangahau he kimi i tētahi huarahi ōhanga ake. Nā te mea, ko te iti o te pūngao e hiahiatia ana hei whāngai i te waro ki roto i te pākia o te tinana, ko te nui ake o te pūngao ka taea te whakamahi hei whakaoho i te tipu, i te whakaputanga rānei. Engari kāore he huarahi pēnei i roto i te taiao. "Ko te kitenga o ngā whākōkī ranu me ngā mahi maha i hiahiatia he auahatanga," te kī a Tobias Erb. "Heoi, ko te kitenga o ngā whākōkī kaitono he tīmatanga noa iho. Kei te kōrero tātou mō ngā tauhohenga ka taea te tatau tahi nā te mea he tino puhoi - i ētahi wā, he iti iho i te kotahi te tauhohenga ia hekona mō ia whākōkī. Ka taea e ngā tauhohenga taiao te haere i te tere e kotahi mano ngā wā tere ake." Koinei te wāhi e uru mai ai te matū koiora hangai, e kī ana a Maren Nattermann: "Ki te mōhio koe ki te hanganga me te tikanga o tētahi whākōkī, ka mōhio koe ki hea hei wawao. He tino painga tēnei."
He maha ngā huarahi e whakamahia ana mō te arotau i ngā whākōkī: te whakawhiti poraka hanga motuhake, te whakaputa ira whakarerekētanga matapōkere, me te whiriwhiri i te kaha. "He tino pai te formate me te formaldehyde nā te mea ka taea e rāua te uru ki roto i ngā pakitara pūtau. Ka taea e tātou te tāpiri i te formate ki te reo ahurea pūtau, ka puta he whākōkī e huri ai te formaldehyde hua hei tae kōwhai kore-paitini i muri i ētahi haora," te kī a Maren. I whakamārama a Nattermann.
Kāore e taea ngā hua i roto i tētahi wā poto nei me te kore te whakamahinga o ngā tikanga whakaputa tere. Hei whakatutuki i tēnei, i mahi tahi ngā kairangahau me te hoa ahumahi a Festo i Esslingen, Tiamana. "Whai muri i te 4,000 ngā rerekētanga, i whakawhāhia e mātou te hua," te kī a Maren Nattermann. "Nō reira, kua hangaia e mātou te pūtake mō te tipu o te tauira moroiti E. coli, te hoiho mahi moroiti o te hangarau koiora, i runga i te waikawa formic. Heoi, i tēnei wā, ka taea anake e ō tātou pūtau te whakaputa formaldehyde, ā, kāore e taea te whakarerekē anō."
I te mahi tahi me tana hoa mahi a Sebastian Wink mai i te Institute of Plant Molecular Physiology. Kei te whakawhanake ngā kairangahau a Max Planck i tētahi momo ka taea te tango i ngā takawaenga me te whakauru i aua mea ki roto i te pūnaha pākia matua. I taua wā anō, kei te whakahaerehia e te tīma he rangahau mō te huringa hikohiko o te hauhā waro ki te waikawa formic me tētahi rōpū mahi i te Institute of Chemical Energy Conversion. Nā Max Planck i raro i te arataki a Walter Leitner. Ko te whāinga roa he "pūhara kotahi-rahi-e-mō-te-katoa" mai i te hauhā waro i hangaia e ngā tukanga hiko-matū ki ngā hua pēnei i te insulin, te biodiesel rānei.
Tohutoro: Maren Nattermann, Sebastian Wenk, Pascal Pfister, Hai He, Seung Hwang Lee, Witold Szymanski, Nils Guntermann, Faiying Zhu “Te whakawhanaketanga o tētahi rerenga hou mō te hurihanga o te phosphate-dependent formate ki te formaldehyde i roto i te vitro me te in vivo”, Lennart Nickel. , Charlotte Wallner, Jan Zarzycki, Nicole Pachia, Nina Gaisert, Giancarlo Francio, Walter Leitner, Ramon Gonzalez, me Tobias J. Erb, Mei 9, 2023, Nature Communications.DOI: 10.1038/s41467-023-38072-w
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