E whakaatu ana ngā hua o tētahi rangahau a tētahi rōpū nō Te Whare Wānanga o Shanghai Jiaotong he tohu mimi tairongo te waikawa formic ka taea te kite i te mate a Alzheimer i te wā tōmua (AD). Mā ēnei kitenga ka taea te whakatakoto huarahi mō te tirotiro papatipu iti te utu, ā, he watea hoki. I whakaputa a Tākuta Yifan Wang, Tākuta Qihao Guo me ōna hoa mahi i tētahi tuhinga ko "Systematic Evaluation of Formic Acid in Mine as a New Potential Alzheimer's Biomarker" te taitara i roto i te Frontiers in Aging Neuroscience. I roto i tā rātou kōrero, i whakatau ngā kaituhi: "He tino tairongo te waikawa formic i roto i te mimi mō te tirotiro wawe mō te mate a Alzheimer… He watea, he ohanga hoki te kite i ngā tohu o te mate a Alzheimer i roto i te mimi. Me whakauru ki roto i te tirotiro hauora o ia rā o ngā kaumātua."
E whakamārama ana ngā kaituhi ko te AD, te momo tino noa o te mate wareware, e tohuhia ana e te ngoikore haere o te hinengaro me te whanonga. Ko ngā āhuatanga matua o te AD ko te kohikohinga rerekē o te amyloid β (Aβ) o waho o te pūtau, te kohikohinga rerekē o ngā neurofibrillary tau tangles, me te kino o te synapse. Heoi, i haere tonu te tīma, "kāore i te tino mārama te pathogenesis o te AD."
Kāore e kitea te mate a Alzheimer tae noa ki te wā kua roa rawa te rongoā. "He mate mau tonu, he mate huna hoki, ko te tikanga ka taea te whanake me te mau tonu mō ngā tau maha i mua i te putanga mai o te ngoikore o te hinengaro," te kī a ngā kaituhi. "Ka puta ngā wāhanga tōmua o te mate i mua i te wāhanga o te mate wareware kāore e taea te whakakore, he matapihi koura tēnei mō te wawaotanga me te maimoatanga. Nō reira, he mea tika kia tirotirohia whānuitia te mate a Alzheimer i te wāhanga tōmua o te hunga kaumātua."
Ahakoa he āwhina ngā kaupapa tirotiro papatipu ki te kite i te mate i te wā tōmua, he uaua rawa, he utu nui hoki ngā tikanga tātaritanga o nāianei mō te tirotiro noa. Ka taea e te Positron emission tomography-computed tomography (PET-CET) te kite i ngā putunga Aβ tōmua, engari he utu nui, ā, ka tūpono ngā tūroro ki te irahiko, ko ngā whakamātautau biomarker e āwhina ana ki te tautuhi i te mate a Alzheimer me tango toto whakaeke, me wero rānei i te lumbar hei tiki wai cerebrospinal, he mea whakarihariha pea ki ngā tūroro.
E ai ki ngā kairangahau, kua whakaatuhia e ētahi rangahau he taea te tirotiro i ngā tūroro mō ngā tohu mimi o te AD. Kāore he pokanoa o te mimi, ā, he watea hoki, he mea tino pai mō te tirotiro whānui. Ahakoa kua tautuhia e ngā kaipūtaiao ngā tohu mimi mō te AD i mua, kāore tētahi e tika ana mō te kite i ngā wāhanga tōmua o te mate, ko te tikanga kei te ngaro tonu te matapihi koura mō te maimoatanga tōmua.
Kua rangahauhia e Wang mā i mua te formaldehyde hei tohu i te mate a Alzheimer i roto i te mimi. "I ngā tau tata nei, kua kitea te pākia o te formaldehyde rerekē hei tetahi o ngā āhuatanga matua o te ngoikore o te hinengaro e pā ana ki te koroheketanga," ko tā rātou. "I kōrerohia e tā mātou rangahau o mua he hononga i waenga i ngā taumata formaldehyde mimi me te mahi hinengaro, e kī ana ko te formaldehyde mimi he tohu pea mō te tautuhi wawe i te AD."
Heoi anō, kei reira tonu ngā wāhi hei whakapai ake i te whakamahinga o te formaldehyde hei tohu koiora mō te kitenga wawe i te mate. I roto i tā rātou rangahau i whakaputaina tata nei, i arotahi te tīma ki te formate, he matūkai formaldehyde, kia kite ai mēnā he pai ake tana mahi hei tohu koiora.
I roto i te rōpū rangahau he 574 ngā tāngata, tae atu ki ngā tūroro he mate a Alzheimer o ngā momo kaha rerekē, me ngā kaiuru whakahaere hauora pai. I tātarihia e ngā kairangahau ngā tauira mimi me te toto mai i ngā kaiuru ki te rapu i ngā rerekētanga o ngā tohu koiora mimi, ā, i whakahaerehia he aromatawai hinengaro. I wehea ngā kaiuru ki ngā rōpū e rima i runga i ā rātou tātaritanga: he pai te hinengaro (NC) 71 ngā tāngata, he hekenga hinengaro whaiaro (SCD) 101, kāore he ngoikore hinengaro ngawari (CINM), he ngoikore hinengaro 131, he ngoikore hinengaro ngawari (MCI) 158 ngā tāngata, me te 113 he BA.
I kitea i roto i te rangahau he nui ake te pikinga o ngā taumata waikawa formic mimi i roto i ngā rōpū mate a Alzheimer katoa, ā, he hononga ki te hekenga o te hinengaro ki te whakataurite ki ngā rōpū hauora, tae atu ki te rōpū hekenga hinengaro ā-tinana i te tīmatanga. E whakaatu ana tēnei ko te waikawa formic pea te tohu tairongo mō te wāhanga tōmua o te AD. "I roto i tēnei rangahau, mō te wā tuatahi ka pūrongo mātou ka rerekē ngā taumata waikawa formic mimi me te hekenga o te hinengaro," ko tā rātou. "Kua whakaatuhia e te waikawa formic mimi he whai huatanga ahurei ki te tautuhi i te AD. Hei tāpiri, i tino piki ake te waikawa formic mimi i roto i te rōpū tautuhi SCD, ko te tikanga ka taea te whakamahi i te waikawa formic mimi mō te tautuhi wawe i te AD."
He mea whakamīharo, i te tātaritanga a ngā kairangahau i ngā taumata o te mimi me ngā tohu koiora o te mate Alzheimer i roto i te toto, i kitea e rātou ka taea e rātou te matapae tika ake i te taumata o te mate i roto i ngā tūroro. Heoi, me nui ake ngā rangahau hei mārama ki te hononga i waenga i te mate Alzheimer me te waikawa formic.
Heoi, ko te whakatau a ngā kaituhi: "Ehara i te mea ka taea anake te whakamahi i ngā taumata mimi formate me te formaldehyde hei wehewehe i te AD mai i te NC, engari ka taea hoki te whakapai ake i te tika o te matapae o ngā tohu koiora plasma mō te wāhanga o te mate AD. ngā tohu koiora pea mō te tātaritanga".