Ka whakamahia e mātou ngā pihikete hei whakapai ake i tō wheako. Mā te haere tonu ki te tirotiro i tēnei pae, e whakaae ana koe ki tā mātou whakamahinga o ngā pihikete. Ētahi atu kōrero.
Mā te pāwhiri i te "Whakaaetia Katoa", e whakaae ana koe ki te rokiroki pihikete ki tō pūrere hei whakapai ake i te whakatere pae, hei tātari i te whakamahinga o te pae, hei tautoko hoki i tā mātou whakarato i ngā ihirangi pūtaiao kore utu, tuwhera hoki. Ētahi atu kōrero.
Ka taea e te whakamātautau mimi ngāwari te kite i te mate a Alzheimer i te wā tōmua, ka whakatakoto huarahi mō ngā kaupapa tirotiro papatipu? E whakaatu pono ana te rangahau hou a Frontiers in Aging Neuroscience i tēnei. I whakamatautauria e ngā kairangahau tētahi rōpū nui o ngā tūroro Alzheimer o ngā momo kaha me ngā tāngata hauora he pai te hinengaro kia kitea ai ngā rerekētanga o ngā tohu koiora mimi.
I kitea e rātou ko te waikawa formic i roto i te mimi he tohu tairongo o te hekenga hinengaro whaiaro, ā, tera pea he tohu mō ngā wāhanga tōmua o te mate a Alzheimer. He utu nui, he uaua, ā, kāore e taea te tirotiro noa i ngā tikanga o nāianei mō te tautuhi i te mate a Alzheimer. Ko te tikanga o tēnei, ko te nuinga o ngā tūroro ka tautuhia ina kua roa rawa te maimoatanga whai hua. Heoi, ko te tātaritanga mimi kore-whakaeke, iti te utu, me te watea mō te waikawa formic pea te mea e tonoa ana e ngā tākuta mō te tirotiro wawe.
"He mate mau tonu, he mate huna hoki te mate a Alzheimer, arā, ka taea te whanake me te mau tonu mō ngā tau maha i mua i te putanga mai o te ngoikore o te hinengaro," te kī a ngā kaituhi. "Ka puta ngā wāhanga tōmua o te mate i mua i te wāhanga o te mate wareware kāore e taea te whakakore, he matapihi koura tēnei mō te wawaotanga me te maimoatanga. Nō reira, he mea tika kia tirotirohia whānuitia te mate a Alzheimer i te wāhanga tōmua o te hunga kaumātua."
Nō reira, ki te mea he mea nui te wawaotanga wawe, he aha ai kāore tātou e whai kaupapa tirotiro auau mō te mate a Alzheimer i te wā tōmua? Ko te raruraru kei roto i ngā tikanga tātaritanga e whakamahia ana e ngā tākuta i tēnei wā. Kei roto i ēnei ko te tomography tukunga positron o te roro, he mea utu nui, ā, ka pāngia ngā tūroro e te irahiko. Kei reira anō hoki ngā whakamātautau biomarker ka taea te kite i te mate a Alzheimer, engari me tango toto whakaeke, me wero rānei i te lumbar hei whiwhi wai cerebrospinal, he mea e whakaroahia ana e ngā tūroro.
Heoi, kāore e pokanoa te whakamātautau mimi, ā, he watea hoki, he mea pai mō te tirotiro whānui. Ahakoa kua tautuhia e ngā kairangahau ngā tohu mimi mō te mate a Alzheimer i mua, kāore he mea e tika ana mō te kite i ngā wāhanga tōmua o te mate, ko te tikanga kei te ngaro tonu te matapihi koura mō te maimoatanga tōmua.
Kua rangahauhia e ngā kairangahau o te rangahau hou tētahi matū waro e kiia nei ko te formaldehyde hei tohu mimi mō te mate a Alzheimer. Heoi, he wāhi hei whakapai ake i te kitenga wawe i te mate. I roto i tēnei rangahau hou, i arotahi rātou ki te formate, he matū whakaputa formaldehyde, kia kite ai mēnā he pai ake tana mahi hei tohu tohu.
E 574 ngā tāngata katoa i whai wāhi ki te rangahau, ā, ko ngā kaiuru he tūao hauora noa iho, he hauora hoki ō rātou hinengaro, he rerekē rānei ngā taumata o te whanaketanga o te mate, mai i te hekenga o te hinengaro ki te tino mate. I tātarihia e ngā kairangahau ngā tauira mimi me te toto o ngā kaiuru, ā, i whakahaerehia he aromatawai hinengaro.
I kitea i roto i te rangahau he nui ake te pikinga o ngā taumata waikawa formic i roto i te mimi i roto i ngā rōpū mate a Alzheimer katoa, ā, he hononga ki te hekenga o te hinengaro ki te whakataurite ki ngā rōpū hauora, tae atu ki te rōpū hekenga hinengaro ā-tinana i te tīmatanga. E kī ana tēnei he tohu tairongo pea te waikawa formic mō ngā wāhanga tōmua o te mate a Alzheimer.
He mea whakamīharo, i te tātaritanga a ngā kairangahau i ngā taumata mimi me ngā tohu toto mō te mate a Alzheimer, i kitea e rātou ka taea e rātou te matapae tika ake i te wāhanga o te mate e pāngia ana e te tūroro. Heoi, me nui ake ngā rangahau hei mārama ki te hononga i waenga i te mate a Alzheimer me te waikawa formic.
"Kua whakaatuhia e te waikawa formic mimi te tino aro ki te tirotiro wawe mō te mate a Alzheimer," te kī a ngā kaituhi. "He watea, he iti hoki te utu mō te whakamātautau tohu koiora mimi mō te mate a Alzheimer, ā, me whakauru ki roto i ngā tirotiro hauora o ia rā mō te hunga kaumātua."
Wang, Y. et al. (2022) Arotake pūnaha o te waikawa formic mimi hei tohu koiora hou pea mō te mate a Alzheimer. Ngā rohe i roto i te koiora io o te koroheketanga. doi.org/10.3389/fnagi.2022.1046066.
Ngā tohu: te koroheketanga, te mate a Alzheimer, ngā tohu koiora, te toto, te roro, te mau tonu, ngā mate mau tonu, ngā matū, te mate wareware, te tātaritanga, ngā tākuta, te formaldehyde, te neurology, te positron emission tomography, te rangahau, te tomography, te mimi
I te Pittcon 2023 i Philadelphia, Pennsylvania, i uiuitia e mātou a Ahorangi Joseph Wang, te toa o te Tohu Ralph N. Adams mō te Matū Tātari o tēnei tau, mō te maha o ngā whakamahinga o te hangarau pūoko koiora.
I roto i tēnei uiuinga, ka matapakihia e mātou te koiora manawa me pēhea e taea ai e ia te whakamahi hei taputapu whai hua hei ako i ngā tohu koiora mō te kimi wawe i ngā mate, me Mariana Leal, te Kaiārahi Rōpū i Owlstone Medical.
Hei wāhanga o tā mātou arotake SLAS US 2023, ka matapakihia e mātou te taiwhanga o te heke mai me tōna āhua pea me Luigi Da Via, te Kaiārahi o te Rōpū Whakawhanake Whakamātautau GSK.
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