Ko te paparanga piri o waho o ngā harore me ngā huakita, e kiia nei ko te "extracellular matrix" ECM rānei, he rite te matotoru ki te tiēre, ā, he paparanga tiaki me te anga tiaki. Engari e ai ki tētahi rangahau hou i roto i te puka iScience, i whakahaerehia e te Whare Wānanga o Massachusetts Amherst i te mahi tahi me te Worcester Polytechnic Institute, ka hanga te ECM o ētahi moroiti i te tiēre i te aroaro o te waikawa oxalic, ētahi atu waikawa māmā rānei. Nā te mea he mahi nui tā te ECM i roto i ngā mea katoa mai i te ātete ki ngā paturopi ki ngā paipa kua purua me te poke o ngā taputapu hauora, ko te mārama ki te whakahaere a ngā moroiti i ō rātou paparanga tiēre piri he pānga whānui ki ō tātou oranga o ia rā.

"He hiahia tonu tōku ki ngā ECM moroiti," te kī a Barry Goodell, he ahorangi moroiti i te Whare Wānanga o Massachusetts Amherst me te kaituhi matua o te pepa. "He maha ngā tāngata e whakaaro ana ki te ECM hei paparanga tiaki o waho e tiaki ana i ngā moroiti. Engari ka taea hoki e ia te mahi hei ara mo ngā matūkai me ngā whākōkī ki roto, ki waho hoki i ngā pūtau moroiti."
He maha ngā mahi a te paninga: nā tōna piri ka taea e ngā moroiti takitahi te huihui tahi hei hanga koroni, hei "kiriata koiora" rānei, ā, ki te nui ngā moroiti e mahi ana i tēnei, ka taea e ia te aukati i ngā paipa, te poke rānei i ngā taputapu hauora.
Engari me uru hoki te anga ki roto: he maha ngā moroiti e tuku ana i ngā whākōkī me ētahi atu matūkai mā te ECM, ki roto i te rauemi e hiahia ana rātou ki te kai, ki te pangia rānei (pērā i te rakau pirau, i te kiko tuaiwi rānei), ā, ina oti te mahi a ngā whākōkī, ko te mahi nakunaku – te whakahoki i ngā matūkai mā te ECM.
Ko te tikanga o tēnei, ehara te ECM i te paparanga tiaki kore mahi noa iho; Inaa, e ai ki tā Goodell mā i whakaatu, te āhua nei he kaha ngā moroiti ki te whakahaere i te matotoru o tā rātou ECM, nō reira, tōna uruhanga. Me pēhea tā rātou mahi?
I roto i ngā harore, ko te mea i puta mai he waikawa oxalic, he waikawa rauropi noa e puta noa ana i roto i te maha o ngā tipu, ā, e ai ki ngā kitenga a Goodell me āna hoa mahi, he maha ngā moroiti e whakamahi ana i te waikawa oxalic e puta mai ana i a rātou hei here ki ngā paparanga o waho o ngā warowaihā. , ECM rite ki te tiēre.
Engari i te tirohanga tata atu a te tīma, i kitea e rātou ehara i te mea ko te waikawa oxalic anake te mea i āwhina i te whakaputa i te ECM, engari i "whakahaere" hoki: ko te nui ake o te waikawa oxalic i tāpirihia e ngā moroiti ki te ranunga warowaihā-waikawa, ka nui ake te matotoru o te ECM. Ko te nui ake o te matotoru o te ECM, ka nui ake te aukati i ngā ngota nui kei uru, kei puta rānei i te moroiti, ko ngā ngota iti ake ka noho wātea ki te tomo ki te moroiti mai i te taiao, me te ritenga kē.
E wero ana tēnei kitenga i te māramatanga pūtaiao tuku iho mō te āhua o te urunga atu o ngā momo matū rerekē e tukuna ana e ngā harore me ngā huakita mai i ēnei moroiti ki te taiao. I kī a Goodell mā, i ētahi wā, me whakawhirinaki atu ngā moroiti ki te whakaputanga o ngā ngota iti rawa hei whakaeke i te pūtake, i te kiko rānei e whakawhirinakihia ana e te moroiti kia ora ai, kia pangia rānei. Ko te tikanga o tēnei, tera pea ka whai wāhi nui te whakaputanga o ngā ngota iti ki te pathogenesis mēnā kāore e taea e ngā whākōkī nui ake te haere mā roto i te pūtake moroiti i waho o te pūtau.
"Te āhua nei he ara waenga," te kī a Goodell, "ka taea e ngā moroiti te whakahaere i ngā taumata waikawa kia urutau ki tētahi taiao motuhake, me te pupuri i ētahi o ngā ngota nui ake, pērā i ngā whākōkī, me te tuku i ngā ngota iti kia ngāwari te haere mā roto i te ECM. "Ko te whakarerekētanga o te ECM me te waikawa oxalic he huarahi pea mā ngā moroiti ki te tiaki i a rātou anō mai i ngā patu huakita me ngā paturopi, nā te mea he maha o ēnei rongoā he ngota tino nui. Koinei te kaha whakaritenga pea hei kī ki te wikitoria i tētahi o ngā arai nui i roto i te rongoā patu huakita, nā te mea ko te whakahaere i te ECM kia ngāwari ake te uruhanga ka taea te whakapai ake i te whai huatanga o ngā patu huakita me ngā patu huakita."

"Mēnā ka taea e tātou te whakahaere i te hanga koiora me te tukunga o ngā waikawa iti pēnei i te oxalate i roto i ētahi moroiti, ka taea hoki e tātou te whakahaere i ngā mea e uru ana ki roto i ngā moroiti, ka taea ai e tātou te rongoā pai ake i ngā mate moroiti maha," te kī a Goodell.
I te Hakihea 2022, i whiwhi te tohunga koiora moroiti a Yasu Morita i tētahi tahua mai i te National Institutes of Health hei tautoko i ngā rangahau e aro ana ki te whakawhanake i ngā maimoatanga hou, whai hua ake mō te mate kohi.

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